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Synthesis of new 4,7Chloroquinoline Derivatives by using Ultrasound irradiation evaluation of their Biological activity

  • Unique Paper ID: 170555
  • Volume: 11
  • Issue: 7
  • PageNo: 1269-1273
  • Abstract:
  • This study describes the click synthesis of new 4, 7-chloroquinoline derivatives by using ultrasound irradiation and evaluation of their compounds show activity antimicrobial, anti malarial and the anticancer. All high compounds chow moderate anti malarial activity with 100 MM, sis of them showed anti malarial activity chloroquinoline derivative screened for their antitumor cancer) 2. 3. 4. 68 and 95 with IC50 M The compound 19 Also the newly synthesized compounds we were activity towards three lines of cancer cells. MCF-7 (human breast HCT-116 (colon cartinomal (9) exerted the highest activity and Hela (Cervical carcinoma) cell lines. Compound (3) and on all cell lines and showed special selectivity toward MCF-7 cells and the antibacterial screening data showed moderate ta 11.3) towards the entire tested good inhibition zone (12.5-0.63-238 compounds. Elucidation of the structures of these new pure compounds was based on, IR, 'H NMR, C NAMR, MS and their elemental analysis.
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  • ISSN: 2349-6002
  • Volume: 11
  • Issue: 7
  • PageNo: 1269-1273

Synthesis of new 4,7Chloroquinoline Derivatives by using Ultrasound irradiation evaluation of their Biological activity

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