Treatment resistance in Genitourinary Cancer

  • Unique Paper ID: 172010
  • Volume: 11
  • Issue: 8
  • PageNo: 1625-1627
  • Abstract:
  • Treatment resistance in genitourinary (GU) cancers, including prostate, bladder, and kidney cancers, significantly limits the effectiveness of therapies, leading to disease progression. Resistance mechanisms include enhanced DNA repair, metabolic reprogramming, altered apoptotic pathways, immune evasion, and genetic adaptations. Chemotherapy, immunotherapy, and targeted therapies are frequently undermined by these mechanisms. Emerging strategies to overcome resistance involve combination therapies, targeting specific molecular pathways, and personalized medicine approaches. Recent advances, such as the role of circular RNAs and novel agents like belzutifan, offer promising avenues to counteract resistance and improve patient outcomes.

Cite This Article

  • ISSN: 2349-6002
  • Volume: 11
  • Issue: 8
  • PageNo: 1625-1627

Treatment resistance in Genitourinary Cancer

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