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A REVIEW ON FORMULATION AND EVALUATION OF BUCCAL PATCHES

  • Unique Paper ID: 177090
  • Volume: 11
  • Issue: 12
  • PageNo: 362-372
  • Abstract:
  • Drugs that are administered via the buccal mucosa directly go into the systemic circulation, thereby avoiding hepatic first-pass metabolism. As a result, this administration route is useful for improving the bioavailability of drugs that are subject to a broad first-pass effect when delivered orally. For the oral mucosal route of drug administration, different types of dosage forms can be formed. A sublingual tablet can afford rapid drug absorption and an exact pharmacological effect; however, the duration of delivery is short owing to the inevitable loss of a large proportion of the administered dose due to swallowing. To keep away from such losses, a patch can be formulated that is placed on the buccal mucosa of the oral cavity. But this approach is limited by the thicker dimensions of the buccal membrane compared to the others that line the oral cavity and constraints impelled by the delivery system itself (the amount of drug reaching the systemic circulation is limited by the area of the mucosa that the patch covers, which, for patient comfort reasons, is relatively small). A direct estimate of the systemic circulation through the internal jugular vein bypasses drugs from the hepatic first-pass metabolism showing high bioavailability.
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  • ISSN: 2349-6002
  • Volume: 11
  • Issue: 12
  • PageNo: 362-372

A REVIEW ON FORMULATION AND EVALUATION OF BUCCAL PATCHES

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8.01 (Year 2024)
UGC Approved
Journal no 47859

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