Copyright © 2025 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

@article{151319,
        author = {Dr. Anandrao A. Kale and Pratiksha Hinge and Pooja  Gate},
        title = {Synthesis and Bioactivity of Dihydropyrimidinone Derivatives Containing Phthalimide Moiety. },
        journal = {International Journal of Innovative Research in Technology},
        year = {},
        volume = {7},
        number = {12},
        pages = {426-431},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=151319},
        abstract = {A simple and precise synthesis   method that have been used to synthesis of hybrid compounds containing dihydropyrimidinone and phthalimide   moieties.  The 2-(4-acetyl-phenyl)-1H-isoindole-1,3 (2H)dione.(III) derivatives  were synthesized (Scheme-I) by refluxing phthalic anhydride (I)  and para-aminoacetophenone (II) in glacial acetic acid for 2 hr. Newly synthesized 2-(4-acetylphenyl)-1H-isoindole-1,3(2H)-dione (III), by refluxing with dimethylformamide-dimethylacetal (DMF-DMA) without solvent for 12 h.gives enaminone, 2-{4-[(2E)-3-(dimethylamino)prop-2-enoyl]phenyl}-1H-isoindole-1,3(2H)-dione (IV),  The  enaminone, 2-{4-[(2E)-3-(dimethylamino)prop-2-enoyl]phenyl}-1H-isoindole-1,3(2H)-dione (IV), used for synthesis of  new series of novel Biginelli compounds,5-benzoyl-substituted phenyl-3,4-dihydropyrimidin-2(1H)-one-1H-isoindole-1,3(2H)-dione (Va-Vb),  The compounds(V-a to V-d) obtained were identified using physical and spectroscopic 1HNMR, 13CNMR and  Mass ) A series of novel dihydropyrimidinone derivatives containing phthalimide moiety were synthesized with good yield, at high purity, and in efficient manner from the enaminone, which was derived from phthalimide by simple and solvent-free method. Compound Va-Vd was tested for antibacterial strain Escherichia coli (E. coli) by Agar well diffusion method.  It has been observed that tested compounds Vb and Vc shows good antibacterial activities against Escherichia coli (E.coli) bacterial strains.},
        keywords = {DHPMs, Biginelli Synthesis, Antibacterial analysis, Escherichia coli (E.coli)},
        month = {},
        }