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@article{151436,
        author = {PAVITHRA V},
        title = {a review article on caffiene activity},
        journal = {International Journal of Innovative Research in Technology},
        year = {},
        volume = {7},
        number = {12},
        pages = {618-621},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=151436},
        abstract = {Caffeine (1,3,7-trimethylxanthine) is the most consumed psychoactive substance in the 
world, acting by means of antagonism to adenosine receptors, mainly A1 and A2A. Coffee is the 
main natural source of the alkaloid which is quite soluble and well extracted during the brew’s 
preparation.  After consumption, caffeine is almost completely absorbed and extensively 
metabolized in the liver by phase I (cytochrome P450) enzymes, mainly CYP1A2, which appears to 
be polymorphically distributed in human populations.  Paraxanthine is the major caffeine 
metabolite in plasma, while methylated xanthine and methyl uric acids are the main metabolites 
excreted in urine. In addition to stimulating the central nervous system, caffeine exerts positive 
effects in the body, often in association with other substances, contributing to prevention of 
several chronic diseases.  The potential adverse effects of caffeine have also been extensively 
studied in animal species and in humans.},
        keywords = {},
        month = {},
        }