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@article{159014,
        author = {Tanuja M. Panaskar and Nilesh R. Bhosale and Rajashri S. Chavan and Pooja B. Khatate and Prajakta H. Nale and Tejas T. Ombase and Ankita V. Bhosale},
        title = {FORMULATION AND EVALUATION OF MICROEMULSION BASED HYDROGEL FOR TOPICAL DELIVERY},
        journal = {International Journal of Innovative Research in Technology},
        year = {},
        volume = {9},
        number = {11},
        pages = {160-166},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=159014},
        abstract = {The purpose of this study was to construct a posaconazole hydrogel based on a microemulsion and characterize it in order to use it as a topical administration system. The solubility of posaconazole was done in different excipients. FTIR spectroscopy was used to conduct a study on the compatibility of drugs and excipients. Pseudoternary phase diagrams were built to determine the region of existence of microemulsions. Posaconazole loaded oil in water (o/w) microemulsion was made by phase titration method. To study the impact of independent variables, such as the ratio of surfactant to co-surfactant and the ratio of oil to water, on dependent variables, such as %transmittance, viscosity, and %cumulative drug release at 4 hours, a 32full factorial design was used. The improved formulation F9 demonstrated in vitro drug release for up to 4 hours. The physical appearance, pH, viscosity, spreadability, and in vitro permeability of a posaconazole microemulsion-based hydrogel were all adjusted. Antifungal activity was high in the optimized formulation. The results of the stability research demonstrated that the optimized formulation was sufficiently stable for one month.},
        keywords = {Topical drug delivery, pseudoternary phase diagrams, microemulsion based hydrogel, posaconazole, 32 factorial design, antifungal activity.},
        month = {},
        }