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@article{166806,
        author = {Tharcitus Chilaka Onwudiwe and Cynthia Uloaku Ogbuagu and Chidi Uzoma Igwe and Sunday Chieme Chukwudoruo and Tharcitus Chilaka Onwudiwe and Mark Udo and Emmanuel Onyebuchi Ogbuagu},
        title = {Ameliorative Effect of Irish Potato Tuber, Unripe Plantain and Unripe Pawpaw Fruits Combination Beverage on Indomethacin-Induced Ulcer in Albino Rats},
        journal = {International Journal of Innovative Research in Technology},
        year = {2024},
        volume = {11},
        number = {2},
        pages = {2572-2580},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=166806},
        abstract = {Peptic ulcer is one of the most common gastrointestinal disorders, which affects the world wide population. The present study was designed to assess the ameliorative effect of Iris potato tuber, unripe plantain and unripe pawpaw fruits combination beverage on indomethacin-induced ulcer in albino rats. Assessment of individual, binary and ternary combinations of the plant beverage extract was carried out by randomizing 40 male albino rats into ten groups (n=4), inducing ulcer in the rats with 30 mg/kg bw of indomethacin and treating with various beverages. Oral acute toxicity and histopathological tests were also conducted. Among the individual beverage extracts, irish potato beverage extract (Ir) produced the highest (94.59 ±2.36%) antiulcer activity, whereas binary combination of irish potato and unripe pawpaw (Ir+Pw) beverage extract was found to have the highest (94.27±2.00%) antiulcer effect when compared with the other combinations. Result of acute toxicity recorded no mortality up to the limit test dose of 5000 mg/kg bw. Results of histopathological examination showed indomethacin induced effect in the stomach were reversed by irish potato and unripe pawpaw (Ir+Pw) combination beverage extract. The observed healing potential of the beverage extract may be linked to presence of bioactive compounds in the plants. Therefore we recommend further studies to elucidate the bioactive principles responsible for antiulcer activity.},
        keywords = {Beverage; Bioactive; Indomethacin; Ulcer; Histopathological.},
        month = {July},
        }