Development and Evaluation of Mucoadhesive Graft Copolymer of a Natural Polysaccharide Using Microwave Assisted Grafting Technique and Alkaline Hydrolysis

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Neha Prajapati

Development and Evaluation of Mucoadhesive Graft Copolymer of a Natural Polysaccharide Using Microwave Assisted Grafting Technique and Alkaline Hydrolysis

Authors: Neha Prajapati

Unique Paper ID: 167814
Volume: 11
Issue: 4
PageNo: 428-433

Keywords: Grafting High performance biopolymer Mucoadhesive graft copolymer.

Abstract:
Grafting of polymers adds numerous beneficial features to a simple polymer. In this study, natural polysaccharide starch has been grafted with acrylamide monomer by microwave assisted grafting method using ammonium persulfate (APS) as a chemical initiator. Five batches of polyacrylamide grafted copolymers (PAM-g-Starch) i.e. Go, G1, G2, G3 and G4 were prepared by modulating only the microwave radiation time (40s, 60s, 80s, 100s and 120s respectively), keeping all other factors constant. Further to increase the functionality and mucoadhesive property of each graft copolymer, alkaline hydrolysis was carried at 50oC for 1h. Effects of duration of radiation application on the properties of modified polymers were estimated by various evaluation parameters. Grafted polymers were characterized by % grafting, % grafting efficiency, Fourier transform infrared spectroscopy, differential scanning calorimetry, intrinsic viscosity study, elemental analysis, neutralization equivalent and mucoadhesive test. Results show that among all grafted products, batch G1 showed the highest % grafting, % grafting efficiency and NE values (349.5%, 81.95% and 485.6 respectively).

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Cite This Article

ISSN: 2349-6002
Volume: 11
Issue: 4
PageNo: 428-433

Development and Evaluation of Mucoadhesive Graft Copolymer of a Natural Polysaccharide Using Microwave Assisted Grafting Technique and Alkaline Hydrolysis

Available:https://ijirt.org/article?manuscript=167814

Impact Factor
8.01 (Year 2024)

UGC Approved
Journal no 47859

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