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@article{168982,
        author = {A.Suneetha Devi and B.Nagamani and P.Uma Devi and P.Sivalalitha},
        title = {Design and Development of a Colon-Specific Controlled Release System for Tramadol Hydrochloride},
        journal = {International Journal of Innovative Research in Technology},
        year = {2024},
        volume = {11},
        number = {6},
        pages = {94-101},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=168982},
        abstract = {The study developed matrix tablets using guar gum and chitosan, with an EUDRAGIT L100 coating, for colon-specific delivery of Tramadol hydrochloride.
FT-IR analysis showed no significant drug-excipient interactions. Powder flow properties and tablet physical characteristics met acceptable standards. In vitro studies indicated that drug release was influenced by guar gum content, with higher levels promoting sustained release. Formulations F1 to F7 achieved better controlled release, while F8 showed increased pH sensitivity due to the absence of guar gum and chitosan. EUDRAGIT L100 coating reduced drug release in the upper GIT, enhancing colon-specific delivery.},
        keywords = {Tramadol hydrochloride, Colon-specific drug delivery, Guar gum, Chitosan, EUDRAGIT L100, Matrix tablets, Controlled release, Polysaccharides.},
        month = {November},
        }