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@article{169931,
        author = {Mahesh Kailas Wagh and Suraj Sanjay Shelar and Proff.Mrs.Dipali Kothawade},
        title = {"Breaking Barriers: The Development of Oral Insulin Therapy"},
        journal = {International Journal of Innovative Research in Technology},
        year = {2024},
        volume = {11},
        number = {6},
        pages = {2749-2754},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=169931},
        abstract = {Diabetes mellitus (DM) is a prevalent metabolic disorder with significant mortality rates, prompting the need for effective management strategies. Current insulin therapies primarily rely on parenteral administration, which poses challenges such as patient discomfort and local tissue complications. This review explores the development of oral insulin therapy as a promising alternative, aimed at enhancing patient compliance and mimicking physiological insulin release. We discuss the mechanisms of diabetes, the hurdles faced in oral insulin delivery, and recent advancements in formulation technologies. Key innovations include nanoparticle delivery systems, enteric coatings, and peptide conjugates, which aim to improve insulin stability and absorption in the gastrointestinal tract. The potential of polymeric nanoparticles, particularly, offers significant benefits in oral insulin administration, paving the way for more effective diabetes management solutions.},
        keywords = {Diabetes Mellitus (DM), Therapy, Insulin, Polymeric Nanoparticles, Bioavailability, Controlled Release, Patient Compliance,  Solid Lipid Nanoparticles, Resistance.},
        month = {November},
        }