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@article{171638,
        author = {harsh vardhan katariya and kashish parvani},
        title = {Formulation and evaluation of a niosome-based gel for the treatment of fungal infections},
        journal = {International Journal of Innovative Research in Technology},
        year = {2024},
        volume = {11},
        number = {8},
        pages = {370-376},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=171638},
        abstract = {Fungi as pathogens are a growing concern in global health, even more with their rising resistance to standard antifungal treatment. Niosomes, non-ionic surfactant-based vesicles, are emerging drug delivery systems with great promise, particularly in improving bioavailability, targeted delivery, and sustained release of drug substances. This article reviews the formulation and evaluation of niosome-based gels for treatment against fungal infections towards alternatives intervention of the existing antifungal therapies. Important areas discussed were preparation methods of niosomes such as thin-film hydration, reverse-phase evaporation, etc., surfactant composition, size, and encapsulation efficiency, and their roles in antifungal effectiveness. It also discusses the formulation and evaluation of niosomes and how they may be used for therapeutic purposes, combining the advantages of both niosomes and gels whilst increasing skin penetration and prolonging drug release. Evaluation methods include in vitro and in vivo methodology, while gel characteristics include viscosity, spreadability, and skin irritation. Future directions in the development of gels based on niosomes for the treatment of fungal infections are therefore discussed in detail; thus, providing an overview on the challenges in the future from clinical applications toward better patient outcomes with respect to niosome-based gels will be received in such a perspective.},
        keywords = {Fungal infections, Antifungal resistance, Drug delivery systems, Gel formulation, Gel evaluation, Patient outcomes, Niosome-based gel therapy},
        month = {December},
        }