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@article{172736,
        author = {P. S. Sathvik Reddy and Suddakanti Pooja and Polisetty Swetha and G.Varun Reddy},
        title = {Advanced Liver Fibrosis Diagnosis In Nafld: A Combined Approach  Using Biomarkers And Demographics},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {11},
        number = {9},
        pages = {744-751},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=172736},
        abstract = {Individuals having the disease of nonalcoholic fatty liver disease (NAFLD), a precise diagnosis of severe liver fibrosis is essential to stopping the disease's progression and directing treatment measures. Although liver biopsies are still the gold standard, their invasiveness highlights the need for trustworthy non-invasive substitutes. In order to improve the precision of identifying advanced fibrosis in NAFLD, this study investigates a combination strategy that makes use of blood biomarkers and demographic factors. Demographic variables like age, sex, ethnicity, and comorbidities like diabetes and obesity are combined with biomarkers like fibrosis-specific panels (e.g., FIB-4, NAFLD fibrosis score) and metrics generated from advanced imaging. When compared to stand-alone techniques, the combined model achieves greater sensitivity and specificity by utilizing the advantages of each diagnostic modality. By lowering the need for invasive procedures and facilitating earlier action, this method shows potential for risk classification in clinical practice. Its applicability in a variety of clinical contexts and demographics requires additional validation through prospective research. It’s the crucial step in reduction of the course, the exact diagnosis of severe liver fibrosis is crucial for preventing non-alcoholic fatty liver disease, mortality and liver-related comorbidities. A crucial stage of NAFLD, advanced fibrosis indicates dangerous hepatocellular and hepatocellular carcinoma, therefore early and accurate identification is essential. Despite being the gold standard, traditional liver biopsies are not widely used in clinical practice because they are expensive, invasive, and can easily having sample errors. Imaging and serum biomarkers for the non-invasive methods like have become attractive substitutes and they frequently don't provide reliable diagnostics on their own.},
        keywords = {Hepatic fibrosis, NAFLD, advanced fibrosis, FIB-4, NFS, logistic regression.},
        month = {February},
        }