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@article{173712,
        author = {M Hemanth Kumar and Saravana P and Bharath Kumar K and Anshu Beulah Ram},
        title = {A study on the anti-cancer, anti-oxidant and anti-bacterial activities of Alternanthera ficoidea (L.) R. Br against human breast cancer cells (MCF-7)},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {11},
        number = {10},
        pages = {1447-1458},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=173712},
        abstract = {Background: Breast cancer is a major cause of cancer-related deaths worldwide. It could be caused by various factors like increasing age, obesity, harmful use of alcohol etc. Objectives : This research aimed to investigate the antioxidant, antibacterial, and anticancer activities of Alternanthera ficoidea (L.) R. Br. Methods : Different parts of the plant extract were prepared, DPPH assay for antioxidant activity, Disc diffusion assay for antibacterial activity and MTT assay for anticancer activity were determined using standard assay protocol. Cell cycle studies and GC-MS analysis were performed on leaf extract. Result: Leaf extract showed significant activity as antioxidant activity (IC50=130.2µg/mL), antibacterial activity (20 ± 0.6 mm) against Staphylococcus aureus and Escherichia coli shows negative results and anticancer activity (IC50 = 61.36µg/mL). Cell cycle studies showed arrest of cells at “G0-G1” and “S”-phase. GC-MS results showed key components with antioxidant, anticancer compounds, and anti-inflammatory activities. Conclusion: Plant based medicines are safer and reliable. Given these promising results, Alternanthera ficoidea presents a valuable opportunity for developing novel plant-based drugs for cancer treatment.},
        keywords = {Alternanthera ficoidea; Anti-cancer activity; MTT assay; GC-MS; Cytotoxicity; Anti-oxidant activity; Anti-bacterial activity; Flow cytometry.},
        month = {March},
        }