FORMULATION AND EVALUATION OF BHRINGRAJ EXTRACT GEL FOR THE TREATMENT OF FOLLICULITIS

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Mr. J.N.B. Indusekhar; Dr Bhaskara Raju Vatchavai; Miss. Namburi Varshini

FORMULATION AND EVALUATION OF BHRINGRAJ EXTRACT GEL FOR THE TREATMENT OF FOLLICULITIS

Authors: Mr. J.N.B. Indusekhar, Dr Bhaskara Raju Vatchavai, Miss. Namburi Varshini

Unique Paper ID: 174086
Volume: 11
Issue: 10
PageNo: 4714-4720

Keywords: Bhringraj Anti-Foliculitis gel Anti Inflammatory Anti-Oxidant Anti-Bacterial

Abstract:
Staphylococcus aureus and Klebsiella pneumoniae are the main bacterial infections that produce foliculitis, a common skin ailment that causes inflammation and irritation. The goal of the current study is to create and assess a Carbopol 940 gel based on Bhringraj (Eclipta prostrata) extract utilizing a hydroalcoholic solvent solution in order to determine whether it has anti-folliculitis properties. The extract was made via hydroalcoholic extraction, and its active phytoconstituents were identified by UV spectrophotometry. The antibacterial activity of the prepared gel against S. aureus and K. pneumoniae was assessed using the agar disc diffusion technique, with Ciprofloxacin serving as the standard reference. Its effectiveness against these infections was demonstrated by the findings, which showed strong antibacterial activity with inhibition zones similar to those of the usual medication. Furthermore, the extract's antioxidant ability was evaluated using the DPPH free radical scavenging test, which revealed that it plays a part in counteracting oxidative stress, which fuels skin inflammation. The anti-inflammatory activity of the extract was investigated utilizing the goat blood hemolysis technique in order to further assess its therapeutic effectiveness. Hemolysis was significantly reduced in the results, suggesting strong anti-inflammatory qualities that are essential for reducing folliculitis symptoms. The Bhringraj gel formulation demonstrated high stability, spreadability, and pH appropriateness for topical use. According to the study's findings, the strong antibacterial, antioxidant, and anti-inflammatory qualities of Bhringraj extract-based Carbopol 940 gel make it a promising natural and efficient treatment option for bacterial folliculitis. Its therapeutic potential has to be established by more clinical research.

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Cite This Article

ISSN: 2349-6002
Volume: 11
Issue: 10
PageNo: 4714-4720

FORMULATION AND EVALUATION OF BHRINGRAJ EXTRACT GEL FOR THE TREATMENT OF FOLLICULITIS

Available:https://ijirt.org/article?manuscript=174086

Impact Factor
8.01 (Year 2024)

UGC Approved
Journal no 47859

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