A Review of Chronobiology-Based Drug Delivery Systems

  • Unique Paper ID: 174352
  • PageNo: 3569-3576
  • Abstract:
  • The field of chronopharmacology explores the impact of biological rhythms on drug efficacy and safety, leading to the emergence of chronobiology-based drug delivery systems. These systems optimize therapeutic outcomes by aligning drug release with the body’s natural biological cycles, enhancing efficacy while minimizing adverse effects. This review provides an overview of chronopharmacology principles, existing drug delivery technologies, and advancements in chronotherapeutics. Various delivery approaches, including pulsatile, programmable, and stimuli-responsive systems, are discussed in the context of conditions such as cardiovascular diseases, asthma, and cancer. Challenges and prospects in developing chronobiology-driven drug formulations are also explored, highlighting their potential in personalized medicine.

Copyright & License

Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

BibTeX

@article{174352,
        author = {Aniqua Tajassum Sattar Sheikh and Kundan Jaiishwar Singh and Gule Samreen Kazi and Rupali Sunil Suryawanshi and Tiksha Prashant Yerne and Riya Prashant Ghate and Avantika Vitthal Pofare and Pratik Deepak Dhokne},
        title = {A Review of Chronobiology-Based Drug Delivery Systems},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {11},
        number = {10},
        pages = {3569-3576},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=174352},
        abstract = {The field of chronopharmacology explores the impact of biological rhythms on drug efficacy and safety, leading to the emergence of chronobiology-based drug delivery systems. These systems optimize therapeutic outcomes by aligning drug release with the body’s natural biological cycles, enhancing efficacy while minimizing adverse effects. This review provides an overview of chronopharmacology principles, existing drug delivery technologies, and advancements in chronotherapeutics. Various delivery approaches, including pulsatile, programmable, and stimuli-responsive systems, are discussed in the context of conditions such as cardiovascular diseases, asthma, and cancer. Challenges and prospects in developing chronobiology-driven drug formulations are also explored, highlighting their potential in personalized medicine.},
        keywords = {Chronopharmacology, Chronotherapy, Drug Delivery System, Biological Rhythms, Circadian Cycle, Pulsatile Release, Personalized Medicine, Chronobiology},
        month = {March},
        }

Cite This Article

Sheikh, A. T. S., & Singh, K. J., & Kazi, G. S., & Suryawanshi, R. S., & Yerne, T. P., & Ghate, R. P., & Pofare, A. V., & Dhokne, P. D. (2025). A Review of Chronobiology-Based Drug Delivery Systems. International Journal of Innovative Research in Technology (IJIRT), 11(10), 3569–3576.

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