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@article{174398,
        author = {I.Bala Tripura Sundari and I.Sruthi},
        title = {Preparation and Characterization of Trandolapril Buccal Patch},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {11},
        number = {10},
        pages = {3743-3750},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=174398},
        abstract = {The buccal area provides a desirable route for systemic medication administration. The present study aims to formulate and evaluate trandolapril buccal Patch to avoid the first-pass hepatic metabolism of the drug and improve bioavailability. Various combinations of mucoadhesive polymers like PVA, HPMC K10, HPMC E15, SCMC, HPMC K100, Eudragit RL-100, and Eudragit-RS 100 were tried. These formulations were evaluated for visual inspection, content uniformity, surface pH, swelling index, thickness variation, assay, in-vitro drug release, folding endurance, bio-adhesion time, and Ex-vivo permeation studies. The best-selected formulation showed an in-vitro drug release of 97.5% and an Ex-vivo drug release of 98.8% in one hour and 30 minutes. Mucoadhesive patches of trandolapril can be developed as release formulations for the treatment of hypertension.},
        keywords = {Trandolapril, Buccal patch, PVA, HPMC K10, HPMC E15, SCMC, HPMC K100},
        month = {March},
        }