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@article{175793,
        author = {Karuna Kumari Earni and Dr Narayana Raju. Padala and Dr.V.Bhaskara raju and Karishma Begum Shaik and Vasanthi Kadagalla and Siddabattula Snigdha Sri and k.kanaka venkata lakshmi},
        title = {Formulation and Evaluation of sodium alginate based wound healing films with Diclofenac sodium},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {11},
        number = {11},
        pages = {4110-4118},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=175793},
        abstract = {In order to improve healing efficacy, the current study is to create and assess wound healing films based on sodium alginate that are combined with diclofenac sodium and additional bioactive substances. Sodium alginate, a naturally occurring biopolymer with moisture- retentive and biocompatible qualities, was mixed with hydroxypropyl methylcellulose (HPMC) to increase mechanical strength and film-forming capacity. To lessen discomfort and inflammation at the wound site, diclofenac sodium, a non-steroidal anti-inflammatory medicine (NSAID), was used. To stop infection and encourage healing, zinc oxide—known for its antibacterial and tissue-regeneration qualities—was added. Glycerin and polyethylene glycol (PEG) were employed as plasticisers to increase skin adhesion and flexibility. The films' physical characteristics, drug release behaviour, antibacterial activity, and capacity for wound healing were assessed after they were made using the solvent casting process. The formulation is a viable option for efficient wound care because of the synergistic effect of the bioactive components, which provided anti-inflammatory, antibacterial, and tissue- regenerative properties.},
        keywords = {Anti-bacterial, Anti-inflammatory, Tissue Regeneration, Solvent Casting, Bioadhesive,Skin Permeation, Topical Diclofenac, Fabrication.},
        month = {April},
        }