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@article{176011,
        author = {SRINIVASA SUMNATH KAMATHAM and V. BHASKARA RAJU and K. LAKSHMI PRASANNA and K. NAGA SATYA and R. CHIRU PUSHPA SREE and V. LEELA and V. MANOJ},
        title = {MITOCHONDRIAL MANIPULATION IN CANCER THERAPY –A REVIEW},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {11},
        number = {11},
        pages = {6981-6989},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=176011},
        abstract = {Mitochondria are crucial for energy production and biosynthesis in cells, but they also play a significant role in cancer progression. Growing evidence suggests that mitochondrial bioenergetics, dynamics, and signalling are involved in cancer cell functions such as motility, stemness, proliferation, and survival. In some cancer cells, mitochondria adapt to the tumor's needs, potentially becoming "oncogenic mitochondria" that help spread cancer. Metabolic alterations, including changes in mitochondrial function, are key factors in cancer development. Reactive oxygen species, byproducts of various biological functions, have been extensively studied for their role in cancer. Modulating Reactive oxygen species levels has shown promise in cancer therapies, including immunotherapies, with positive results in preclinical studies. To target mitochondria more effectively, researchers are developing mitochondriotropic ligands and multifunctional nanoplatforms for cancer treatment. These platforms aim to induce mitochondria mediated apoptosis in tumor cells through strategies like chemotherapy, photothermal therapy, photodynamic therapy, chemodynamic therapy, sonodynamic therapy, radiodynamic therapy, and combined immunotherapy, though challenges remain in optimizing these approaches.},
        keywords = {Reactive oxygen species, Apoptisis, Sonodynamic therapies, oncogenic mitochondria.},
        month = {April},
        }