Haematological Evaluation of Beta vulgaris in Alloxan-Induced Diabetic Swiss Albino Mice

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Anupam Bharti; Navodita Priyadarshani

Haematological Evaluation of Beta vulgaris in Alloxan-Induced Diabetic Swiss Albino Mice

Authors: Anupam Bharti, Navodita Priyadarshani

Unique Paper ID: 176437
Volume: 11
Issue: 11
PageNo: 6861-6865

Keywords: Beta vulgaris diabetes mellitus haematological parameters RBC count haemoglobin packed cell volume (PCV) mean corpuscular volume (MCV)

Abstract:
Diabetes mellitus, a metabolic disorder characterized by chronic hyperglycaemia, can lead to severe haematological alterations. This study evaluates the effects of Beta vulgaris (beetroot) ethanolic extract on haematological parameters in alloxan-induced diabetic Swiss albino mice. A total of 50 mice were divided into five groups: normal control, extract-treated control, diabetic control, and two diabetic groups treated with different doses of Beta vulgaris. Haematological indices including RBC count, haemoglobin, packed cell volume (PCV), and mean corpuscular volume (MCV) were assessed at 10, 20, and 30 days. The results showed that the diabetic control group (Group C) exhibited a significant decrease in RBC count, haemoglobin concentration, and PCV, and an increase in MCV compared to the control group. Treatment with Beta vulgaris resulted in a dose-dependent improvement in these parameters. Group E (diabetic + high-dose Beta vulgaris) showed near-normal values for RBC count (7.2 ± 0.3 million/mm³), haemoglobin (13.0 ± 0.3 g/dL), and PCV (40.5 ± 0.3%), and a normalization of MCV (85.0 ± 0.8 fL) by day 30. The study demonstrates that Beta vulgaris has a significant potential to improve haematological abnormalities in diabetic mice, supporting its therapeutic application for managing diabetes-related haematological complications.

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Cite This Article

ISSN: 2349-6002
Volume: 11
Issue: 11
PageNo: 6861-6865

Haematological Evaluation of Beta vulgaris in Alloxan-Induced Diabetic Swiss Albino Mice

Available:https://ijirt.org/article?manuscript=176437

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8.01 (Year 2024)

UGC Approved
Journal no 47859

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