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@article{178070,
        author = {Ms. Tejashree Balaso Burungale and Ms. Sanjyot Sadashiv Borate and Mrs. Charushila Bhintade and Dr. H.D. Jedage},
        title = {Method Development and Validation of Cefotaxime Sodium by UV Spectroscopy},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {11},
        number = {12},
        pages = {4412-4422},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=178070},
        abstract = {A simple, rapid, and cost-effective UV spectrophotometric method was developed and validated for the quantitative estimation of cefotaxime sodium in bulk and pharmaceutical dosage forms. The method is based on the measurement of absorbance at 227 nm in distilled water, where cefotaxime sodium exhibited a significant absorbance peak. The calibration curve was linear in the concentration range of 5–30 µg/mL with a correlation coefficient (R²) greater than 0.995, demonstrating excellent linearity. 
Method validation was carried out as per ICH guidelines, evaluating parameters such as linearity, accuracy, precision, specificity, and robustness. The accuracy of the method was confirmed by recovery studies, which showed results within the acceptable limits (98–102%). The method exhibited good intra-day and inter-day precision with low relative standard deviation (RSD) values. The proposed method is suitable for routine quality control analysis of cefotaxime sodium in bulk drug and pharmaceutical formulations due to its simplicity, sensitivity, and reliability.},
        keywords = {Uv spectrometer, Validation,absorbance},
        month = {May},
        }