Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

@article{178501,
        author = {Helly Sheth and Ketkee Mandawar and Dr. Pratyush Jain and Dr. Manisha Tandon},
        title = {Formulation Strategy and Optimization of Betahistine-Encapsulated Microspheres},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {11},
        number = {12},
        pages = {3441-3443},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=178501},
        abstract = {Betahistine, a histamine analog, is widely used for the treatment of vertigo, tinnitus, and Meniere’s disease—conditions associated with vestibular disorders and inner ear dysfunction. Despite its therapeutic potential, Betahistine’s clinical effectiveness is limited due to its short half-life, rapid systemic clearance, and low oral bioavailability. To address these challenges, polymeric microspheres—particularly those formulated with biodegradable materials such as poly(lactic-co-glycolic acid) (PLGA) and chitosan—offer promising avenues for controlled and sustained drug release. The present study focuses on the formulation and optimization of Betahistine-loaded microspheres, with the aim of developing a scalable and commercially viable drug delivery system.},
        keywords = {PLGA, Chitosan, Microspheres, solvent evaporation},
        month = {July},
        }