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@article{178825,
        author = {Avishkar Zagday and Vinay Upadhyay},
        title = {Pharmacodynamic Profiling of Ultra-High Dilution Cuprum Metallicum in PTZ-Evoked Petit Mal Epilepsy(Absence Seizures) Using Murine Experimental Paradigms},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {11},
        number = {12},
        pages = {5047-5052},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=178825},
        abstract = {Aims-To assess the pharmacodynamic effects of Cu-prum Metallicum.(CM), Objectives: To investigate the anticonvulsant effect of homeopathic remedy Cuprum Metallicum on mice and its comparison with standard therapeutic diazepam. Materials and Methods: Male Swiss Albino Mice were taken and divided into 6 groups comprising 6mice in each group. The first group was treated as control; the second group re-ceived PTZ((Pentylenetetrazol): 80 mg/kg i.p. to induce seizures, third group received Diazepam (4 mg/kg i.p.) + PTZ, fourth group was given CM 6 C +PTZ, fifth group was given CM 30+ PTZ and sixth group was given CM 200+PTZ. The Clonic Convulsion model for Absence Seizures was used and the latent period was observed and statistically analysed. Results: All three potencies (6, 30,200) of homeopathic preparation of Cuprum Metallicum exhibited Antiepileptic activity, Cuprum 200 offering best protection against Seizures more than standard AntiEpileptic drug Diazepam. Conclusion: Our study demonstrated efficacy of Cu-prum Metallicum in Petil Mal epilepsy management.},
        keywords = {Cuprum Metallicum, Homeopathy, Anticonvulsant, Epilepsy},
        month = {May},
        }