Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

@article{180853,
        author = {SYED AREEFULLA HUSSAINY and Munnaza Fatima},
        title = {FORMULATION AND EVALUATION OF FLUVASTATIN FLOATING MICROSPHERES},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {1},
        pages = {6232-6246},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=180853},
        abstract = {The present study is to formulate floating Microspheres of Fluvastatin with a view to control the release of the drug. From the experimental results, it can be concluded that FT-IR study shows no significant shifting of the peaks. Therefore, it confirms the short term stability of the drug in the microspheres. Biocompatible polymers like HPMC K100M, Ethyl cellulose and Eudragit S 100 can be used to formulate floating Microspheres. Good percentage drug entrapment and practical yields were obtained with the polymers. The flow properties of all formulations were within the acceptable range and therefore they could be easily filled into capsules. The floating microspheres of drug with HPMC and Ethyl cellulose were buoyant while those with Eudragit S 100 showed greater buoyancy. Cumulative percentage drug release significantly decreased with increase in polymer concentration. The overall curve fitting into various mathematical models was found to be on average. The formulations F8 best fitted into zero order and showed Non-Fickian diffusion mechanism. Formulated microspheres were stable and compatible at the room temperature and accelerated temperature and humidity in storage for 90days. From the stability studies it was found that there was no significant change in the drug entrapment, release characteristics of the microspheres.},
        keywords = {Biodegradable microspheres, emulsion solvent evaporation, fluvastatin sodium, Eudragit S 100},
        month = {July},
        }