Genotoxicity estimation by calculating Mitotic index with Chromosomal aberrations induced by aqua-alcoholic extract of Annona muricata leave

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Jigyasa Chandravanshi; Ankur Chhari and Sameena Akhter; Shazia Khan and Divya Patel; Sarfaraz Hanfi

Genotoxicity estimation by calculating Mitotic index with Chromosomal aberrations induced by aqua-alcoholic extract of Annona muricata leave

Authors: Jigyasa Chandravanshi, Ankur Chhari and Sameena Akhter, Shazia Khan and Divya Patel, Sarfaraz Hanfi

Unique Paper ID: 182602
Volume: 12
Issue: 2
PageNo: 2638-2646

Keywords: Annona muricata L. Genotoxicity Trypan Blue Exclusion assay anti-cancer.

Abstract:
Genotoxins are chemicals that causes DNA damage, potentially leading to heritable mutations in germ cells or cancer in somatic cells, with test available to assess their effects and safety, which is basically termed as genotoxicity, which can lead to chromosomal disorders which results in changes in chromosomes number or structure leading to growth and development issues. Nowadays, medicinal plants are preferred for the solution of such kind of diseases, many scientists and researchers around the world are working for appropriate solution. Annona muricata L., known as Soursop, is a tropical plant used in traditional medicine for its anti-inflammatory, anti-diabetic, anti-cancer properties and other activities. It’s main components are Annonaceous, Acetogenins and other chemical compounds. Microscopic observation of different types of chromosomal aberrations induced by aqua-alcoholic extraction of Annona muricata on cultured lymphocytes and the Silver and Chitosan based nanoparticles of its leaves extract was used in this study for the calculation of mitotic index, performed Chromosomal aberration assay, Trypsin binding or G-binding of chromosomes for their clear identification and Trypan Blue Exclusion assay for determining cell viability by using healthy lymphocytes exhibits good results with satisfactory antioxidant activity by using DPPH method.

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Cite This Article

ISSN: 2349-6002
Volume: 12
Issue: 2
PageNo: 2638-2646

Genotoxicity estimation by calculating Mitotic index with Chromosomal aberrations induced by aqua-alcoholic extract of Annona muricata leave

Available:https://ijirt.org/Article?manuscript=182602

Impact Factor
8.01 (Year 2024)

UGC Approved
Journal no 47859

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