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@article{182789,
        author = {Sushma Singh and Saumya Awasthi},
        title = {Exploring Marine Natural Products for Neuroprotection: A Multifaceted Approach to Combat Oxidative Stress and Neuroinflammation},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {2},
        pages = {3764-3770},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=182789},
        abstract = {Neurodegenerative diseases (NDs), such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, represent a critical global health challenge characterized by progressive neuronal loss and cognitive decline. Central to their pathology are the intertwined mechanisms of neuroinflammation and oxidative stress, which exacerbate neuronal damage. This review explores the emerging potential of marine-derived natural products as neuroprotective agents targeting these processes. Marine ecosystems provide a rich repository of bioactive compounds, including polysaccharides, alkaloids, terpenoids, and polyphenols, which exhibit potent antioxidant and anti-inflammatory activities. Recent advancements in the pharmacological evaluation of these compounds demonstrate their ability to modulate key signaling pathways, enhance mitochondrial function, and mitigate apoptosis, positioning them as promising candidates for neurotherapeutic development. However, challenges related to bioavailability, blood-brain barrier penetration, and clinical translation persist. Innovative strategies, including advanced drug delivery systems and synthetic biology, offer promising solutions to these barriers. This review underscores the therapeutic promise of marine bioactives in addressing the unmet clinical needs of NDs while advocating for sustained interdisciplinary research efforts.},
        keywords = {Neurodegenerative diseases, marine-derived natural products, neuroinflammation, oxidative stress, Alzheimer's disease, Parkinson's disease, bioactive compounds, neuroprotection, antioxidant, anti-inflammatory.},
        month = {July},
        }