Comparison of Serum Total Testosterone Levels in Controlled versus Uncontrolled Type 2 Diabetes Mellitus Patients

  • Unique Paper ID: 182821
  • PageNo: 3557-3559
  • Abstract:
  • Background:Type 2 diabetes mellitus (T2DM) is commonly associated with hypogonadism. However, the effect of glycemic control on serum testosterone levels remains inadequately studied. Objectives:To compare serum total testosterone (TT) levels in controlled versus uncontrolled male T2DM patients and evaluate the prevalence of androgen deficiency. Materials and Methods:A cross-sectional study was conducted in 100 male T2DM patients aged 35–70 years. Fifty patients with HbA1c <7% were categorized as controlled and 50 with HbA1c >7% as uncontrolled. Serum TT was measured using chemiluminescence immunoassay. Statistical analysis was performed using SPSS v20. Results:Controlled diabetics had significantly higher mean TT levels across all age groups (p<0.0001). Androgen deficiency (TT <300 ng/dL) was present in 48% of uncontrolled vs 16% of controlled diabetics. Conclusion:Good glycemic control is associated with significantly higher testosterone levels. Screening for hypogonadism in uncontrolled T2DM may improve patient outcomes.

Copyright & License

Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

BibTeX

@article{182821,
        author = {Dr. Bonu Hima Sameera and Dr. Simma Sai Aditya and Dr. Kulakarni Jayanth and Dr. E. Sireesha and Dr. K. Siva Prasad},
        title = {Comparison of Serum Total Testosterone Levels in Controlled versus Uncontrolled Type 2 Diabetes Mellitus Patients},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {2},
        pages = {3557-3559},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=182821},
        abstract = {Background:Type 2 diabetes mellitus (T2DM) is commonly associated with hypogonadism. However, the effect of glycemic control on serum testosterone levels remains inadequately studied.
Objectives:To compare serum total testosterone (TT) levels in controlled versus uncontrolled male T2DM patients and evaluate the prevalence of androgen deficiency.
Materials and Methods:A cross-sectional study was conducted in 100 male T2DM patients aged 35–70 years. Fifty patients with HbA1c <7% were categorized as controlled and 50 with HbA1c >7% as uncontrolled. Serum TT was measured using chemiluminescence immunoassay. Statistical analysis was performed using SPSS v20.
Results:Controlled diabetics had significantly higher mean TT levels across all age groups (p<0.0001). Androgen deficiency (TT <300 ng/dL) was present in 48% of uncontrolled vs 16% of controlled diabetics.
Conclusion:Good glycemic control is associated with significantly higher testosterone levels. Screening for hypogonadism in uncontrolled T2DM may improve patient outcomes.},
        keywords = {},
        month = {July},
        }

Cite This Article

Sameera, D. B. H., & Aditya, D. S. S., & Jayanth, D. K., & Sireesha, D. E., & Prasad, D. K. S. (2025). Comparison of Serum Total Testosterone Levels in Controlled versus Uncontrolled Type 2 Diabetes Mellitus Patients. International Journal of Innovative Research in Technology (IJIRT), 12(2), 3557–3559.

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