Synthesis, Characterization Of  Cu(II) Complex Using 5-{(Z)-[(2- HYDROXYPHENYL)METHYLIDENE]AMINO}-1,3,4-THIADIAZOLE-2(3H)-THIONE And Their Anti-fungal, Anti-Inflammatory Property

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Rohit Gawad; Yogesh K. Patil

Synthesis, Characterization Of Cu(II) Complex Using 5-{(Z)-[(2- HYDROXYPHENYL)METHYLIDENE]AMINO}-1,3,4-THIADIAZOLE-2(3H)-THIONE And Their Anti-fungal, Anti-Inflammatory Property

Authors: Rohit Gawad, Yogesh K. Patil

Unique Paper ID: 182860
Volume: 12
Issue: 2
PageNo: 3389-3397

Keywords: Schiff base thiadiazole -[N{3-(5-amino-2-thione-1 3 4 thiadiazole)] metal -(copper) biological activities- (anti-fungal anti-inflammatory)

Abstract:
This study focuses on the synthesis and detailed characterization of a novel Schiff base, 5-{(Z)-[(2-hydroxyphenyl) methylidene] amino}-1,3,4-thiadiazole-2(3H)-thione. The compound was synthesized via the condensation of 1,3,4-thiadiazole-2-thione with salicylaldehyde under mild conditions, producing a high-purity product. Comprehensive structural characterization was conducted using various spectroscopic techniques, such as FT-IR, NMR, and mass spectrometry, confirming the formation of the imine bond and identifying the functional groups typical of the Schiff base. the Schiff base, 5-{(Z)-[(2- HYDROXYPHENYL) METHYLIDENE] AMINO}-1,3,4-THIADIAZOLE-2(3H)-THIONE was reacted with copper (II) ions to form a copper complex. This complex was thoroughly analyzed using UV, FT-IR, which confirmed the successful coordination of copper ions with the Schiff base ligand. Preliminary biological evaluations of the copper complex indicated improved their anti-fungal, anti-inflammatory property.activities compared to the free Schiff base, suggesting its potential in medicinal chemistry applications.This research underscores the versatility of 1,3,4-thiadiazole derivatives in creating new bioactive molecules and demonstrates the enhanced biological activities of their metal complexes. Further studies are encouraged to explore the underlying mechanisms and potential therapeutic uses of these complexes.

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Cite This Article

ISSN: 2349-6002
Volume: 12
Issue: 2
PageNo: 3389-3397

Synthesis, Characterization Of Cu(II) Complex Using 5-{(Z)-[(2- HYDROXYPHENYL)METHYLIDENE]AMINO}-1,3,4-THIADIAZOLE-2(3H)-THIONE And Their Anti-fungal, Anti-Inflammatory Property

Available:https://ijirt.org/article?manuscript=182860

Impact Factor
8.01 (Year 2024)

UGC Approved
Journal no 47859

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