Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

@article{183731,
        author = {Rizwana Sheik kasim and Kavitha Rajendran},
        title = {LL-37: A comprehensive review of its biological functions,mechanisms and therapeutical potential of cathelicidin},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {3},
        pages = {2927-2938},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=183731},
        abstract = {LL-37, a key antimicrobial peptide derived from the precursor hCAP-18, is an essential component of the human innate immune system. As the only member of the cathelicidin family in humans, LL-37 plays a multifaceted role in host defense, antimicrobial activity, immunomodulation, and wound healing. Its broad-spectrum antimicrobial effects, coupled with its capacity to influence immune responses and tissue regeneration, highlight its therapeutic potential. This review will provide an in-depth analysis of LL-37’s structure, biological functions, mechanisms of action, and its emerging therapeutic applications in clinical settings. Furthermore, we will discuss ongoing research efforts aimed at harnessing LL-37 for novel therapeutic strategies, as well as challenges related to its clinical use.},
        keywords = {Antimicrobial peptides, Cathelicidin, hCAP-18, Immune modulation, LL-37, Tissue regeneration, Wound healing},
        month = {August},
        }