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@article{183834,
        author = {Padmanabh B. Deshpande and Gayatri Sutar and Mangesh Bhalekar},
        title = {Validated Stability-indicating HPTLC Method Development for Estimation of Ganciclovir as Bulk Drug and in Capsule Dosage Form},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {3},
        pages = {3279-3283},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=183834},
        abstract = {The present work describes a simple, precise and accurate stability indicating High Performance Thin Layer Chromatography (HPTLC) method development and validation for the determination of Ganciclovir as bulk drug and in capsule dosage form. Forced degradation studies were carried out under various stress conditions according to ICH guidelines to demonstrate the stability-indicating capability of the developed HPTLC method. Chromatographic resolution of Ganciclovir was achieved by using precoated silica gel 60 F254 aluminium plates as the stationary phase and Chloroform: Methanol: Formic Acid (5.5: 4.5: 0.5, v/v/v) as the optimum mobile phase. Densitometric detection was carried out at 254 nm. The retention factor was found to be 0.47 ± 0.05. The developed method was validated concerning linearity, accuracy, precision, limit of detection, limit of quantitation, and robustness as per ICH guidelines. Results found to be linear in the concentration range of 250-1500 ng band-1. The developed method has been applied successfully for the estimation of a drug in capsule dosage form. The developed method can be used for routine quality control analysis of Ganciclovir.},
        keywords = {Ganciclovir, HPTLC, Stability Studies, Validation},
        month = {August},
        }