A Four-Component Cascade Synthesis of Hexahydroquinoline Derivatives at Room Temperature

  • Unique Paper ID: 184722
  • PageNo: 3026-3029
  • Abstract:
  • A sustainable four-component cascade synthesis of hexahydroquinoline derivatives has been developed under mild and environmentally benign conditions. The protocol employs an ethanol–water solvent system at room temperature without the need for catalysts or additives, making the method simple, efficient, and operationally convenient. The reaction proceeds smoothly with a different aldehyde, affording the desired products in good to excellent yields within short reaction times. Compared to traditional approaches, this strategy eliminates harsh reaction conditions, minimizes waste, and aligns with green chemistry principles.

Copyright & License

Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

BibTeX

@article{184722,
        author = {RAJAT KUMAR R and Siva Senthil Kumar B},
        title = {A Four-Component Cascade Synthesis of Hexahydroquinoline Derivatives at Room Temperature},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {4},
        pages = {3026-3029},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=184722},
        abstract = {A sustainable four-component cascade synthesis of hexahydroquinoline derivatives has been developed under mild and environmentally benign conditions. The protocol employs an ethanol–water solvent system at room temperature without the need for catalysts or additives, making the method simple, efficient, and operationally convenient. The reaction proceeds smoothly with a different aldehyde, affording the desired products in good to excellent yields within short reaction times. Compared to traditional approaches, this strategy eliminates harsh reaction conditions, minimizes waste, and aligns with green chemistry principles.},
        keywords = {Cascade synthesis, Hantzsch type reaction, Hexahydroquinolines, Multicomponent reactions (MCR), Green solvents.},
        month = {September},
        }

Cite This Article

R, R. K., & B, S. S. K. (2025). A Four-Component Cascade Synthesis of Hexahydroquinoline Derivatives at Room Temperature. International Journal of Innovative Research in Technology (IJIRT), 12(4), 3026–3029.

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