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@article{185233,
        author = {Shyam Parbat and Sneha Ghodke and Pranjal Chougle and Nilesh Chougule},
        title = {Preparation and evaluation of Ambroxol Hydrochloride fast dissolving tablet by solid dispersion technique},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {5},
        pages = {1082-1100},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=185233},
        abstract = {This study focuses on the preparation and evaluation of Ambroxol hydrochloride fast- dissolving tablets using the solid dispersion technique. Ambroxol hydrochloride, a mucolytic agent with poor aqueous solubility, poses challenges in achieving rapid dissolution and effective bioavailability. Solid dispersion, a promising approach to enhance solubility and dissolution rate, was employed in this research. Various solid dispersion formulations of Ambroxol hydrochloride were prepared using different carriers and methods. The prepared formulations were evaluated for their physicochemical characteristics such as drug content, dissolution rate, and morphology. The results indicated that solid dispersion significantly improved the dissolution rate of Ambroxol hydrochloride, attributing to enhanced drug-carrier interactions and reduced particle size. Fast-dissolving tablets were formulated using the optimized solid dispersion formulation, and there in vitro dissolution behavior was compared with commercially available conventional tablets. The findings suggest that solid dispersion- based fast-dissolving tablets of Ambroxol hydrochloride offer a promising strategy to improve therapeutic efficacy through enhanced dissolution and potentially improved patient compliance.},
        keywords = {Ambroxol hydrochloride, Fast dissolving tablet, Enhanced dissolution rate, Bioavailability, Drug delivery, Solubility enhancement.},
        month = {October},
        }