Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

@article{185583,
        author = {Hemalatha Punati and Sri Venu Madhav Tippabhotla and Sudhakar Poda},
        title = {Phytochemical-Assisted Fabrication of Selenium Nanoparticles: An Eco-Biogenic Approach to Antioxidant Therapy},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {5},
        pages = {2224-2229},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=185583},
        abstract = {Selenium nanoparticles (SeNPs) were synthesized using an eco-friendly, phytochemical-assisted approach with Phyllanthus acidus fruit extract (PFA). The formation of PFA-SeNPs was confirmed by the appearance of a brick-red color and a characteristic surface plasmon resonance peak at 290 nm in the UV-visible spectrum. Scanning electron microscopy revealed that the PFA-SeNPs were irregular in shape, with sizes ranging from 50 to 150 nm, and tended to form loose clusters. The zeta potential of -25.09 mV indicated moderate colloidal stability due to the capping effect of anionic biomolecules from the plant extract. PFA-SeNPs exhibited significant antioxidant activity in a dose-dependent manner, as demonstrated by their ability to scavenge DPPH and ABTS radicals. The nanoparticles also showed promising broad-spectrum antibacterial efficacy against both Gram-positive and Gram-negative bacteria, with inhibition zones increasing with higher concentrations. The enhanced bioactivity of PFA-SeNPs is attributed to the synergistic effect of elemental selenium and the phytochemicals adsorbed on the nanoparticle surface. These findings highlight the potential of PFA-SeNPs as a green and multifunctional nanomaterial for antioxidant and antibacterial applications, with implications for biomedical and therapeutic fields.},
        keywords = {Selenium nanoparticles, Eco-friendly, Antioxidant activity, Antibacterial activity.},
        month = {October},
        }