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@article{185687,
        author = {Ruchi and Mahak Sharma and PRIYA and Priya mahajan},
        title = {Recent progress in the chemistry of dihydropyrimidine derivatives as antibacterial agents},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {5},
        pages = {2443-2453},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=185687},
        abstract = {Antibiotics are becoming increasingly ineffective due to drug resistance, leading to greater difficulty in the treatment of infectious diseases. Therefore, the development of new chemical entities with different mechanisms of action is essential .in the fight against resistant micro-organisms. Various studies have shown that dihydropyrimidine derivatives possess such as antimalarial, anticancer, anti-inflammatory, and antitubercular. Notable among these is antibacterial activity of dihydropyrimidine derivatives. The synthetic flexibility of the pyrimidine ring has led to the development of a wide range of structurally diverse dihydropyrimidine derivatives, which can act at various targets such as inhibit thymidylate synthase or dihydrofolate reductase, interfere with tubulin polymerization, DNA gyrase and topoisomerase IV. This review emphasizes the antibacterial potential of various reported dihydropyrimidine derivatives based on the substitution in the pyrimidine ring. The antibacterial activity is also discussed. This review aims to assemble and scrutinize the latest reports in the promising area of drug development.},
        keywords = {Antibacterial resistance, Dihydropyrimidine derivatives, synthesis, mechanism of action, antibacterial activity.},
        month = {October},
        }