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@article{186012,
        author = {Dr. Kshitija P. Deshmukh and Miss. Supriya D. Sawant and Mr.Vishal Giri and Mr. Vishal Rathod},
        title = {The Hypoglycemic and hypolidaenuc effect of increasing dosages of Allium cepa Aqueous extracts on Alloxan -Induced diabetic Rattus Norvegicus},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {5},
        pages = {4084-4087},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=186012},
        abstract = {This study investigated the hypoglycaemic and hypolipidaemic effects of increasing doses of Allium cepa (onion) aqueous extract in alloxan-induced diabetic Rattus norvegicus. Sixty-three adult Wistar rats were used, of which fifty-four were rendered diabetic through intraperitoneal administration of alloxan monohydrate (150 mg/kg). The diabetic rats were treated for six weeks with A. cepa aqueous extract at doses of 200, 250, and 300 mg/kg, while standard drug controls received glibenclamide at 2.5, 3.8, and 5.0 mg/kg. Blood glucose, total serum lipids, and cholesterol were analysed using standard biochemical methods.
The results showed that A. cepa extract produced a dose-dependent and statistically significant (p < 0.05) reduction in blood glucose, total lipids, and cholesterol levels compared to diabetic controls. The maximum effect was observed at 300 mg/kg, which closely approximated the hypoglycaemic action of glibenclamide. These findings suggest that A. cepa contains bioactive compounds capable of modulating glucose and lipid metabolism and may serve as a potential natural therapeutic agent for the management of diabetes mellitus and its associated lipid abnormalities.},
        keywords = {Allium cepa, Diabetes Mellitus, Hypoglycaemia, Hypolipidaemia, Alloxan, Rattus norvegicus, Glibenclamide},
        month = {November},
        }