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@article{186064,
        author = {Yogita Shinde and Vishal Telvekar},
        title = {Assessment, Evaluation and Validation of Analytical Method for determination of Elemental Impurities in Semecarpus anacardium Seed by ICP-OES},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {6},
        pages = {7634-7645},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=186064},
        abstract = {Since ancient times, majority of people in India have used herbal remedies for the treatment, management, and prevention of many diseases. The use of plant-based medicines as supplements or medications is spreading among the global population. These therapeutic plants can be hazardous or insufficient in nutrients for use by humans and animals. They do this by absorbing trace elements and metals that are present in the soil solutions in ionic, complexed, or chelated forms. In addition to being widely accessible, these medications are also reasonably priced when compared to allopathic treatments. A number of incidents involving heavy metals in herbal medicine have surfaced recently. Regulators have therefore begun to keep an eye on and regulate the quality of herbal medications. The goal of this study is to assess, evaluate, and provide a validated method for determining the content of elemental impurities present in Semecarpus anacardium Seeds. An accurate, precise, reproducible and eco friendly Inductively Coupled Plasma Optical Emission Spectroscopic (ICP – OES) method was developed and validated for the estimation of Calcium, Potassium, Magnesium and Iron in Semecarpus anacardium Seed. The method has been developed and validated using RF power of 1450 W, auxiliary gas of 0.2 L/min, and nebuliser flow of 0.7 L/min and plasma view at axial mode for all elements of interest. The wavelength was monitored for Iron, Magnesium, Calcium and Potassium at 239.562 nm, 285.213 nm, 317.933 and 766.490 nm respectively. The method has been validated in terms of specificity, precision, linearity, accuracy, limit of quantification as per ICH Q2 (R2) Guideline and acceptance criteria for this validation has been obtained from Elemental Impurities-Procedure USP Chapter <233>.The obtained limit of quantification, repeatability, and measurement uncertainty were satisfactory. Linearity results obtained 0.999 and with other statistical data such as slope, y-intercept and Styx at acceptable limit. Recovery estimation with approved reference materials confirmed the method's accuracy. Accuracy of method ranging from 70.23% to 133.37%.},
        keywords = {Semecarpus anacardium, inductively coupled plasma optical emission spectroscopy (ICP-OES), Elemental Impurities, Method Development and Validation, Medicinal plants; multi-elemental analysis, ICH Guideline, USP Chapter <232& 233>.},
        month = {November},
        }