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@article{186086,
        author = {Zeenat Z.H Sutkundikar},
        title = {"CRISPR-Based Therapeutics: Breakthroughs in Targeting Cancer"},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {6},
        pages = {493-499},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=186086},
        abstract = {Cancer continues to be a significant economic and social burden and is the second greatest cause of mortality worldwide. It is brought on by the buildup of genetic and epigenetic changes in two different gene types, proto-oncogenes and tumor suppressor genes (TSGs). Even though our molecular understanding of cancer is still growing, additional work is required to create novel treatment instruments and strategies that make use of these developments. The consistent advancements in genome editing, particularly that which uses programmable nucleases and clustered regularly interspaced short palindromic repeats (CRISPR) to precisely alter genetic material, have opened up a plethora of opportunities to further biomedical research and improve human health. CRISPR/Cas9 systems-mediated gene editing is expected to develop into a useful therapeutic tool for the treatment of some malignancies and hereditary illnesses. The CRISPR-Cas9 system was first employed by bacteria to protect themselves from various bacteriophages. More recently, it has gained noteworthy recognition for its potential to treat genetic diseases and cancer. Another powerful technique for developing animal genetic models for the research and treatment of human genetic illnesses, especially those linked to point mutations, is CRISPR/Cas genome editing. In this review, we have emphasized the role of the CRISPR-Cas9 system in cancer treatment, along with its potential uses in different cancer types and cancer biology, as well as the significant obstacles that must be overcome before it can be clinically applied to a complex and multifactorial disease like cancer.},
        keywords = {Genome editing, CRISPR-Cas9, Tumour suppresser genes (TSGs), Cancer therapy, Genetic and epigenetic changes.},
        month = {November},
        }