COMPARATIVE STUDY OF METHOTREXATE TOPICAL GEL AND CALCIPOTRIOL TOPICAL GEL FOR TRATMENT OF PSORIASIS

  • Unique Paper ID: 186321
  • PageNo: 1138-1142
  • Abstract:
  • Psoriasis is a chronic inflammatory skin condition characterized by red, scaly, and itchy plaques. Topical therapy is preferred for mild to moderate cases. Methotrexate acts as an antimetabolite, reducing inflammation, while Calcipotriol is a vitamin D analogue controlling abnormal keratinocyte growth. This review compares both gels in terms of efficacy, safety, and practical use. Comparative studies have reported that Calcipotriol shows faster onset of action within 2 weeks, whereas Methotrexate provides longer remission periods. Combination therapies showed superior PASI reduction and lower recurrence rates. 1

Copyright & License

Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

BibTeX

@article{186321,
        author = {Vaishnavi phad and Sapna phalke and Gayatri phunne and Mansi pund and Ms.Ayushi kanhed and Dr.Sachidanand Angadi},
        title = {COMPARATIVE STUDY OF METHOTREXATE TOPICAL GEL AND CALCIPOTRIOL TOPICAL GEL FOR TRATMENT OF PSORIASIS},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {6},
        pages = {1138-1142},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=186321},
        abstract = {Psoriasis is a chronic inflammatory skin condition characterized by red, scaly, and itchy plaques. Topical therapy is preferred for mild to moderate cases. Methotrexate acts as an antimetabolite, reducing inflammation, while Calcipotriol is a vitamin D analogue controlling abnormal keratinocyte growth. This review compares both gels in terms of efficacy, safety, and practical use. Comparative studies have reported that Calcipotriol shows faster onset of action within 2 weeks, whereas Methotrexate provides longer remission periods. Combination therapies showed superior PASI reduction and lower recurrence rates. 1},
        keywords = {calcipotriol; methotrexate Pasi score; psoriasis; vitamin d.},
        month = {November},
        }

Cite This Article

phad, V., & phalke, S., & phunne, G., & pund, M., & kanhed, M., & Angadi, D. (2025). COMPARATIVE STUDY OF METHOTREXATE TOPICAL GEL AND CALCIPOTRIOL TOPICAL GEL FOR TRATMENT OF PSORIASIS. International Journal of Innovative Research in Technology (IJIRT), 12(6), 1138–1142.

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