Hyaluronic Acid in Periodontal Regeneration: Evidence, Applications, and Future Prospects

  • Unique Paper ID: 186441
  • PageNo: 2418-2429
  • Abstract:
  • The naturally occurring glycosaminoglycan hyaluronic acid (HA) is crucial for lubrication, wound healing and tissue hydration. Its unique physicochemical and biological characteristics have garnered growing interest in periodontal treatment, particularly in addressing the complex challenge of restoring the damaged periodontal structure. HA functions as an efficient scaffold that promotes cell migration, proliferation, and the development of new blood vessels because of its viscoelastic characteristics. Additionally, its anti-inflammatory, bacteriostatic, and tissue-repairing capabilities position it as a valuable adjunct in both non-surgical and regenerative approaches within periodontics. This review explores the foundational biology, functional mechanisms, and therapeutic applications of HA in periodontal care, emphasizing current research findings and potential future developments in regenerative strategies.

Copyright & License

Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

BibTeX

@article{186441,
        author = {Dr. Shunmuga Prasanth D and Angelina Rayen. S and Sashricka Viswanath and Dr. Aditippriya.B.S and Preethi.G and R.V. Mrudula},
        title = {Hyaluronic Acid in Periodontal Regeneration: Evidence, Applications, and Future Prospects},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {6},
        pages = {2418-2429},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=186441},
        abstract = {The naturally occurring glycosaminoglycan hyaluronic acid (HA) is crucial for lubrication, wound healing and tissue hydration. Its unique physicochemical and biological characteristics have garnered growing interest in periodontal treatment, particularly in addressing the complex challenge of restoring the damaged periodontal structure. HA functions as an efficient scaffold that promotes cell migration, proliferation, and the development of new blood vessels because of its viscoelastic characteristics. Additionally, its anti-inflammatory, bacteriostatic, and tissue-repairing capabilities position it as a valuable adjunct in both non-surgical and regenerative approaches within periodontics. This review explores the foundational biology, functional mechanisms, and therapeutic applications of HA in periodontal care, emphasizing current research findings and potential future developments in regenerative strategies.},
        keywords = {Hyaluronic acid, periodontal regeneration, guided tissue regeneration, wound healing, peri-implant therapy},
        month = {November},
        }

Cite This Article

D, D. S. P., & S, A. R., & Viswanath, S., & Aditippriya.B.S, D., & Preethi.G, , & Mrudula, R. (2025). Hyaluronic Acid in Periodontal Regeneration: Evidence, Applications, and Future Prospects. International Journal of Innovative Research in Technology (IJIRT), 12(6), 2418–2429.

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