Zebrafish as a Translational Model for Human Disease: Applications in Drug Testing and Therapeutic Development.

  • Unique Paper ID: 186468
  • PageNo: 2532-2537
  • Abstract:
  • A potent and adaptable vertebrate model in pharmacological, toxicological, and nanomedical studies is the zebrafish (Danio rerio). Real-time visualization of developmental and disease processes is made possible by their optical transparency, extraordinary genetic resemblance to humans, and ease of genetic manipulation. Zebrafish models offer important insights into metabolic control, brain function, and organ-specific disorders by faithfully simulating intricate human physiological and pathological processes. They are perfect for researching medication efficacy, toxicity, and therapeutic potential because of their versatility in high-throughput screening, cytotoxicity testing, and molecular analysis. Zebrafish are widely utilized as an ethical, economical, and effective substitute for mammalian models in the study of cancer, diabetes, epilepsy, cardiotoxicity, and renal disorders.

Copyright & License

Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

BibTeX

@article{186468,
        author = {Roman Firoj Faras and Swagata S. Godbole},
        title = {Zebrafish as a Translational Model for Human Disease: Applications in Drug Testing and Therapeutic Development.},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {6},
        pages = {2532-2537},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=186468},
        abstract = {A potent and adaptable vertebrate model in pharmacological, toxicological, and nanomedical studies is the zebrafish (Danio rerio). Real-time visualization of developmental and disease processes is made possible by their optical transparency, extraordinary genetic resemblance to humans, and ease of genetic manipulation. Zebrafish models offer important insights into metabolic control, brain function, and organ-specific disorders by faithfully simulating intricate human physiological and pathological processes. They are perfect for researching medication efficacy, toxicity, and therapeutic potential because of their versatility in high-throughput screening, cytotoxicity testing, and molecular analysis. Zebrafish are widely utilized as an ethical, economical, and effective substitute for mammalian models in the study of cancer, diabetes, epilepsy, cardiotoxicity, and renal disorders.},
        keywords = {Zebrafish, in vitro, cell lines, toxicity testing, drug screening, oxidative stress.},
        month = {November},
        }

Cite This Article

Faras, R. F., & Godbole, S. S. (2025). Zebrafish as a Translational Model for Human Disease: Applications in Drug Testing and Therapeutic Development.. International Journal of Innovative Research in Technology (IJIRT), 12(6), 2532–2537.

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