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@article{186531,
        author = {Pankaj Deora and Gurunath V. Pandit and Shailendra V. Dalvi and Serra C. Dias},
        title = {Simultaneous Estimation and Quantification of Paracetamol, Ibuprofen and Caffeine by RP-HPLC Method in Pharmaceutical Dosage},
        journal = {International Journal of Innovative Research in Technology},
        year = {},
        volume = {12},
        number = {no},
        pages = {417-423},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=186531},
        abstract = {A fast and precise HPLC method has been established for simultaneous detection of Paracetamol, Ibuprofen and caffeine. Chromatographic profiling of the three pharmaceuticals was performed on Shimadzu Prominence LC20A System using LiChrospher@ 60 RP –select B of dimension 250 mm length, 4.6 mm ID and 5.0µ Column. The instrument was controlled and data were acquired using Lab Solutions software. A gradient HPLC method was employed using two mobile phases. The Aqueous phase (Mobile phase A) was prepared by dissolving 0.5 g of octane sulfonic acid in 1000 mL Milli-Q water and  orthophosphoric acid was used to adjust the pH to 3.0. Methanol was used as the organic phase (Mobile phase B). The system was run at constant flow rate of 1.0 mL/min. Separation was completed within 25 minutes. The method underwent comprehensive validation assessing parameters such as specificity, precision, linearity, accuracy and robustness. Each parameter was found to fall within the limits recommended by ICH guidelines.},
        keywords = {Paracetamol, Ibuprofen, Caffeine, HPLC, ICH guidelines.},
        month = {},
        }