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@article{187630,
        author = {Prachi B. Desale and Kajal V. Choudhari and Rohit R. Khairnar and Rajanikat T. Kakade and Mohit M.Jadhav},
        title = {Novel Drug Delivery Systems for Herbal Bioactives: A Comprehensive Review of Phytosomes},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {6},
        pages = {5772-5781},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=187630},
        abstract = {Phytosomes are a sophisticated nanotechnology-based delivery platform built specifically to overcome the biopharmaceutical constraints of herbal phytoconstituents. Many plant-derived bioactives have poor aqueous solubility, restricted membrane permeability, fast metabolism, and low oral bioavailability, which limits their therapeutic potential. By establishing a molecular combination between phytochemicals and phospholipids, particularly phosphatidylcholine, phytosomes improve the lipophilicity, gastrointestinal absorption, membrane contact, and overall pharmacokinetic performance of poorly absorbed phytocompounds. This review offers a thorough examination of the structural design, preparation methods, characterisation techniques, and mechanistic foundation of phytosome-mediated drug delivery. It also discusses the important therapeutic applications of phytosomes in inflammation, cancer, hepatoprotection, metabolic disorders, dermatitis, and oxidative stress-related diseases. Preclinical and clinical studies show that phytosomal formulations of flavonoids, terpenoids, polyphenols, and herbal extracts have higher bioavailability, better tissue distribution, improved therapeutic efficacy, and lower dose requirements than conventional herbal preparations. Despite encouraging developments, difficulties like as large-scale manufacturing, stability, regulatory frameworks, and translational clinical data persist. Overall, phytosomes are developing as a strong and adaptable platform for phytopharmaceutical development, providing a scientifically verified strategy to updating herbal treatments for better clinical results.},
        keywords = {Phytosomes, Nanotechnology, Herbal drug delivery, Phytoconstituents, Phospholipids, Phosphatidylcholine.},
        month = {December},
        }