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@article{187888,
        author = {Vaishnavi Mali and Gitanjali Patil and Sariya Shaikh},
        title = {Review on synthesis and screening of the quinoline derivatives as an anti-inflammatory agent},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {7},
        pages = {1-13},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=187888},
        abstract = {Inflammation, a natural defense mechanism, plays a crucial role in protecting living tissues from injury, toxins, and infection. However, excessive release of cytokines can lead to chronic inflammation, contributing to diseases such as cancer and depression. Quinoline derivatives have shown significant promise in medicinal chemistry, possessing analgesic, anti-inflammatory, and anti-cancer properties. This study explores the synthesis and pharmacological activities of quinoline-based compounds, including 7-aminoquinoline derivatives and triazolo-quinolones. The synthesized compounds were characterized using various spectroscopic techniques and evaluated for their anti-inflammatory activity, showing significant edema reduction in mice and rats. The results demonstrate the potential of quinoline derivatives as safer anti-inflammatory agents, with compounds 1A and 1E exhibiting stronger anti-inflammatory action. However, potential side effects, such as gastrointestinal issues and liver enzyme elevation, were also noted. This research contributes to the development of novel quinoline-based anti-inflammatory agents, offering a promising alternative to traditional nsaids.},
        keywords = {},
        month = {November},
        }