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@article{187890,
        author = {Sachin Sanjay Kudnar and Vishal Babasaheb Take and Pankaj Naresh Bhatane and Dharmaraj Yuvraj Sakat and Akanksha Atmaram Kale and Dipali Devidas Girgune and Niranjan S. Tiwari},
        title = {Innovation and preparation of ketoprofen},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {7},
        pages = {60-66},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=187890},
        abstract = {The pharmacokinetic profile of ketoprofen changed as a result of formulation variations brought forth by the study, most notably the addition of different dissolving or extended-release agents. When poloxamer-188 was used as a release modifier, the pharmacokinetic parameters Cmax and AUC of ketoprofen increased the most. Consequently, the pharmacokinetic profile of the medication may be significantly impacted by the use of release modification drugs.Microsponges are drug delivery systems made of porous polymeric microspheres. They improve stability, lessen systemic side effects, and provide a regulated release of medications.
There are numerous preparations and formulations of ketoprofen that are frequently utilized. Solubilizing and prolonging release agents can be used to create different formulations. This investigation sought to ascertain how variations in formulation affected the pharmacokinetic profile of ketoprofen in rats. A literature review was the focus of this study. Between 2011 and 2020, articles were obtained from the ScienceDirect and PubMed databases.
As a member of the nonsteroidal anti-inflammatory medication (NSAID) family, ketoprofen (K) exhibits analgesic, anti-inflammatory, and antipyretic effects. Because of how quickly and well it works, K is one of the most widely utilized NSAIDs. Although K is now utilized to alleviate pain and rheumatic disease symptoms, numerous researchers are searching for further applications for this nutrient.},
        keywords = {Microsponges, Ketoprofen, NSAD, Formulation, pharmacokinetics},
        month = {November},
        }