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@article{188337,
        author = {Dr.Doli Ravali and Dr.Geetha kayla and Dr.Naval kishore},
        title = {cox 2 as a biomarker in the progression and development of gastric carcinoma},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {7},
        pages = {1580-1586},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=188337},
        abstract = {Back Ground: Gastric carcinoma remains a significant global health burden. Cyclooxygenase-2 (COX-2) has been implicated in gastric carcinogenesis and tumor progression. This study investigates COX-2 expression as a potential biomarker in gastric cancer development.
Methods: A prospective analytical study was conducted over 24 months at Osmania General Hospital, Hyderabad. Ninety-eight gastric biopsy specimens were evaluated using routine hematoxylin and eosin (HE) staining and COX-2 immunohistochemistry (IHC). Cox-2 expression was scored based on percentage of stained cells (0: absent, 1: weak, 2: moderate, 3: strong). Statistical analysis employed Chi-square tests with significance threshold at p<0.05.
Results: Males predominated (60.2%, n=59), with mean age 49.5 years. The fundus (39.8%) and body (26.5%) were most frequently involved. Adenocarcinoma represented 20.4% of cases, with 19.3% having gastritis with dysplasia. Strong COX-2 expression (score 3) was observed in 33.7% of cases. No significant correlation was found between COX-2 expression and age, gender, or tumor location (p>0.05). However, a statistically significant association was demonstrated between COX-2 expression scores and histopathological tumor differentiation (p=0.002).
Conclusion: COX-2 overexpression is associated with advanced tumor grades in gastric carcinoma. Routine evaluation of COX-2 expression may serve as a useful adjunctive tool for early detection and prediction of gastric cancer progression, potentially guiding therapeutic strategies.},
        keywords = {COX-2, gastric carcinoma, immunohistochemistry, biomarker, tumor progression},
        month = {December},
        }