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@article{188369,
author = {Miss. Laxmi gajanan kawale and Miss.Anushka D. Akkalwar and Miss Vaishnavi S.Bharti and Miss.Reshma Raju kale and Akib Nisar Khan and Dr.Akshay M. Kasambe and Dr.Avinash S. Jiddewar and Prof. DR. A.M.Kasambe},
title = {A Review On Floting Drug Delivery System: An Innovative Strategy For Prolong Gastric Residence Time},
journal = {International Journal of Innovative Research in Technology},
year = {2025},
volume = {12},
number = {7},
pages = {1516-1523},
issn = {2349-6002},
url = {https://ijirt.org/article?manuscript=188369},
abstract = {Some drugs do not dissolve well in the intestine because of its alkaline pH. As a result, when these drugs are given in normal tablet or capsule form, they pass quickly through the stomach, leading to low bioavailability. Similarly, drugs that are meant to act locally in the stomach also get cleared too fast and do not stay long enough to work effectively. Because of this, patients may need to take the medicine more frequently. To overcome these issues, researchers have developed systems that allow the drug to stay in the stomach for a longer time. One such approach is the Floating Drug Delivery System (FDDS). These systems are designed with low density, allowing them to float on the stomach contents without affecting the normal gastric emptying process. While floating, the drug is slowly released at a controlled rate, which helps maintain steady drug levels in the blood and reduces fluctuations. This review focuses on the formulation, advantages, limitations, and evaluation methods of gastro-retentive floating drug delivery systems, highlighting how they offer improvements over conventional oral dosage forms},
keywords = {Floating Drug Delivery System (FDDS), Gastro-retentive Drug Delivery System (GRDDS), Gastric Retention, Gastric Residence Time (GRT), and Plasma Drug Concentration.},
month = {December},
}
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