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@article{188562,
        author = {Bani Bala and Puspita Roy and Ruchira Swarnakar and Sivangi Srivastava and Sreeja Chakrabarti and Srijita Chatterjee and Dipra Basu and Subhalakshmi Ghosh},
        title = {Flavonoid Phytochemicals: A Promising Reservoir for Novel Antibiotic Discovery},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {7},
        pages = {2188-2210},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=188562},
        abstract = {Flavonoids are a major class of plant secondary metabolites that serve critical roles in plant defence, signalling, and bioactivity, contributing to both plant and human health, and therefore are gaining high attention from the pharmaceutical and healthcare industries. Plants synthesize flavonoids in response to microbial infection, and are found to be a potent antimicrobial agent against a wide range of pathogenic microorganisms in vitro. The substantially promising antibacterial flavonoids not only target bacterial cells selectively, but also inhibit virulence factors, as well as biofilm formation. Moreover, plant derived flavonoids can reverse antibiotic resistance by enhancing drug efficacy through direct destabilization of bacterial membranes, efflux pump inhibition, induction of ROS, interference with essential cellular pathways, and synergistic interactions with conventional antibiotics. These diverse mechanistic pathways underscore flavonoids’ promise in combating multidrug resistant bacterial infection and would provide a molecular rationale for their continued exploration for developing potential antimicrobial drug candidate.},
        keywords = {Medicinal plants; Phytochemicals; Flavonoids; Microbial resistance; Antibiotics},
        month = {January},
        }