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@article{188564,
        author = {Akib Nisar khan and Dr.Akshay M. Kasambe and Dr.Avinash S. Jideewar and Miss. Miss.Reshma Raju kale and Miss. Laxmi gajanan kawale},
        title = {Innovative Horizons in Transdermal Drug Delivery: The Role of Transdermal Patches},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {7},
        pages = {2397-2407},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=188564},
        abstract = {The conventional oral route of drug administration is often challenged by issues like first pass metabolism, resulting in low drug bioavailability. The Transdermal Drug Delivery System(TDDS) was invented to upgrade drug characteristics and avoid these side effects, delivering medication via the skin for local and systemic effects. The transdermal patch is the preferred delivery method, offering advantages such as avoiding first-pass metabolism, providing sustained and controlled drug release, and allowing drug delivery to be stopped immediately if toxicity occurs by simply removing the patch. The first transdermal system was approved by the USFDA in 1979.The skin, the body's largest organ, acts as the primary barrier, composed of the epidermis, dermis, and hypodermis (subcutaneous fat).Drug penetration across the skin occurs via two pathways: the trans epidermal pathway (through the outermost stratum corneum layer via the intracellular or intercellular routes) and the transappendigeal pathway (through hair follicles and sweat glands).},
        keywords = {Anatomy and physiology of skin, drug absorption pathway, types, component’s, evaluation parameters.},
        month = {December},
        }