Copyright © 2025 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

@article{188766,
        author = {Mr. Sandesh Devkate and Dr. Sudarshan Nagrale and Ms. Tejashree Chavan and Ms. Swapnali Chopade},
        title = {A Review on Nose to Brain Drug delivery using Nanoparticles},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {7},
        pages = {3307-3311},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=188766},
        abstract = {The delivery of medications to the central nervous system (CNS) is primarily regulated by the blood-brain barrier (BBB), a structure that prevents the passage of external substances from the bloodstream to the brain's extracellular fluid. Despite the current availability of drugs for neurological disorders affecting millions worldwide that are somewhat effective, they are linked with significant side effects from systemic drug delivery. Conversely, the ability of some medications to penetrate the BBB is hindered by their physicochemical characteristics, resulting in sub-therapeutic levels in their target tissues In this regard, the intranasal route, with its distinctive anatomical features, offers a promising avenue for delivering drugs to the brain. Nanoparticle based systems, in particular, have demonstrated remarkable ability to tackle the obstacles posed by the intranasal route and enable drug delivery to the brain while avoiding systemic distribution. This review addresses recent developments in the use of polymer, lipid, and inorganic nanoparticle les, along with drug nanocrystals, for delivering medications to the brain through intranasal administration. A typical discussion featuring positive perspectives and challenges of this method is also presented.},
        keywords = {Nanoparticle, Delivery from Nose to Brain, Blood-Brain Barrier, lipid based nanoparticles},
        month = {December},
        }