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@article{189028,
        author = {Abhijit A. Botre and Dr Amita B. Dongare and Prof. Poonam. A. Thorat},
        title = {Blood Brain Barrier: Protector of CNS},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {7},
        pages = {4489-4497},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=189028},
        abstract = {The Blood-Brain Barrier (BBB) acts as a selective and dynamic boundary between the peripheral bloodstream and the central nervous system (CNS), playing a vital role in preserving brain homeostasis and protecting neural tissue from harmful substances. This review offers a detailed examination of the structural and functional elements of the BBB, including endothelial cells, tight junctions, astrocytes, and pericytes. We explore the physiological functions of the BBB in controlling molecular transport, immune monitoring, and neuronal communication, as well as its role in neurological conditions like multiple sclerosis, Alzheimer’s disease, and stroke. Additionally, we delve into recent progress in imaging methods, in vitro models, and therapeutic approaches aimed at altering BBB permeability to improve drug delivery to the brain. The BBB is subject to both short-term and long-term regulation, which can be disrupted in pathological conditions. Any drug discovery or delivery program targeting or avoiding the CNS must consider the unique characteristics of the BBB. Blood Brain Barrier restricts the toxins.},
        keywords = {Blood-Brain Barrier (BBB), Central Nervous System (CNS), Neuroprotection, Tight Junctions, Brain Homeostasis, Pericytes, Astrocytes, Neuroinflammation, BBB Permeability.},
        month = {December},
        }