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@article{189515,
        author = {Borude Abhishek R. and Darade Shraddha S. and Darade Krushna K. and Bawane Sakshi B. and Dahale Yashanjali V. and Patil Pragati V and Chavhan Shankar P. and Dr. Gangurde Hemant H},
        title = {A REVIEW ON HERBAL DUAL RELEASE TABLET-IN -TABLET FORMULATION OF CURCUMIN AND PIPERINE FOR ENHANCED BIOAVAILABITY AND THERAPUTIC EFFICACY},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {7},
        pages = {6804-6814},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=189515},
        abstract = {Curcumin, a potent phytoconstituent obtained from Curcuma longa, exhibits wide-ranging pharmacological activities including anti-inflammatory, anticancer, and antioxidant effects; however, its clinical application is limited due to poor aqueous solubility, low bioavailability, and rapid metabolism. Piperine, an alkaloid from Piper nigrum, is known to enhance the bioavailability of various drugs by inhibiting metabolic enzymes and improving intestinal absorption. The tablet-in-tablet dual release system is an innovative oral drug delivery approach that enables the sequential release of two active components with different release profiles. In this formulation concept, piperine is designed for immediate release to enhance absorption, while curcumin is incorporated into a sustained release core to maintain prolonged therapeutic levels. This review highlights the rationale, formulation strategies, release mechanisms, and potential therapeutic advantages of a herbal dual release tablet-in-tablet containing curcumin and piperine. The approach represents a promising advancement in herbal drug delivery, combining traditional phytotherapy with modern pharmaceutical technology to improve efficacy and patient compliance.},
        keywords = {curcumin, piperine, controlled release system, bioavail-ability, therapeutic efficacy.},
        month = {December},
        }